Potential of STAT Somatic Mutation Testing at Resection

State of Mutation Testing at Google

Mutation testing assesses test suite efficacy by inserting small faults into programs and measuring the ability of the test suite to detect them. It is widely considered the strongest test criterion in terms of finding the most faults and it subsumes a number of other coverage criteria. Traditional mutation analysis is computationally prohibitive which hinders its adoption as an industry standa...

Somatic Mutation and Autoimmunity

Upon reading Christopher Goodnow’s recent Review article in Cell, which emphasized the overlapping role of somatic mutation in autoimmunity and cancer (Goodnow, 2007), I was reminded of a graduate lecture course given by Professor Roderick MacLeod in 1995 at the University of Illinois. While introducing F.M. Burnet’s clonal selection theory to our small class, Professor MacLeod mentioned Burnet...

Comparing somatic mutation-callers

Background: Somatic mutation-calling based on DNA from matched tumor-normal patient samples is one of the key tasks carried by many cancer genome projects. One such large-scale project is The Cancer Genome Atlas (TCGA), which is now routinely compiling catalogs of somatic mutations from hundreds of paired tumor-normal DNA exome-sequence data. Nonetheless, mutation calling is still very challeng...

Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples

Background: DNA polymerase β (pol β) is a key enzyme of base excision repair pathway. It is a 1-kb gene consisting of 14 exons. Its catalytic part lies between exon 8 and exon 14. Exon 12 has a role in deoxyribonucleotide triphosphate selection for nucleotide transferase activity. Methods: Genomic DNA was isolated from ovarian carcinoma samples. Single strand conformation polymorphism...

Genotoxicity testing of some metals in the Drosophila wing somatic mutation and recombination test.